CLOCK ELISA Kit for Chicken(Gallus gallus) | EIAab.comCLOCK ELISA Kit for Chicken(Gallus gallus)

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Index > Protein center > CLOCK(Gene name) > Chicken

CLOCK (Gene name),

Circadian locomoter output cycles protein kaput (Protein name ), CLOCK_CHICK from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CLOCK;

Protein name:

Circadian locomoter output cycles protein kaput;

Alternative:

Organism:

Chicken (Gallus gallus).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with BMAL1 is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation. Binds weakly ARNT and ARNT2 to form heterodimers which bind poorly to the E-box motif.

Function:

BMAL1/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. May play a role in DNA damage response (DDR) signaling during the S phase.

Subcellular Location:

Cytoplasm Nucleus Chromosome Shuffling between the cytoplasm and the nucleus is under circadian regulation and is BMAL1-dependent.

Protein Attributes:

Sequence length:

875

Sequence:

50:

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875:

HQPQQQQLSR | HRTDKMTDPS | KAQPQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Gga.2707

String:

Q8QGQ6

Pfam:

PF00010

KEGG:

gga:373991

Uniprot:

Q8QGQ6

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ELISA Kit for Chicken Circadian locomoter output cycles protein kaput

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E15436m

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ELISA Kit for Chicken Circadian locomoter output cycles protein kaput

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E15436r

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96T

ELISA Kit for Chicken Circadian locomoter output cycles protein kaput

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E15436c

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96T

ELISA Kit for Chicken Circadian locomoter output cycles protein kaput

Cat.:

E15436h

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96T

CLIA Kit for Chicken Circadian locomoter output cycles protein kaput

Cat.:

U15436r

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Packing:

96T

CLIA Kit for Chicken Circadian locomoter output cycles protein kaput

Cat.:

U15436c

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Packing:

96T

CLIA Kit for Chicken Circadian locomoter output cycles protein kaput

Cat.:

U15436h

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Chicken Circadian locomoter output cycles protein kaput

Cat.:

U15436m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Chicken Circadian locomoter output cycles protein kaput

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P15436Rb-h

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40ug/0.2ml

Polyclonal Antibody for Chicken Circadian locomoter output cycles protein kaput

Cat.:

P15436Rb-r

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Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Chicken Circadian locomoter output cycles protein kaput

Cat.:

P15436Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Chicken Circadian locomoter output cycles protein kaput

Monoclonal Antibody for Chicken Circadian locomoter output cycles protein kaput

Protein for Chicken Circadian locomoter output cycles protein kaput

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina."
Larkin P. , Baehr W. , Semple-Rowland S.L.
Brain Res. Mol. Brain Res.70:253-263(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;INDUCTION
tissue: Retina.
2.

"Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction."
Chong N.W. , Bernard M. , Klein D.C.
J. Biol. Chem.275:32991-32998(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH ARNTL;INDUCTION;TISSUE SPECIFICITY
3.

"Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation."
Okano T. , Yamamoto K. , Okano K. , Hirota T. , Kasahara T. , Sasaki M. , Takanaka Y. , Fukada Y.
Genes Cells6:825-836(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;TISSUE SPECIFICITY;INDUCTION;INTERACTION WITH ARNTL AND ARNTL2
tissue: Pineal gland.
4.

"CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors."
Haque R. , Ali F.G. , Biscoglia R. , Abey J. , Weller J. , Klein D. , Iuvone P.M.
J. Neurochem.113:1296-1306(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION

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